Antibody fragmentation

Antibody activity is supported by a small region that represents only 2% of the molecule. The rest of the molecule can lead to undesired effects :

• in detection methods, the whole antibody can generate non-specific interactions (background signal)
  
• for therapeutic use, the antibody has an immunogenicity that can cause anaphylactic shocks
  

The antibodies can be treated to obtain fragments F(ab')2 or Fab. The F(ab')2 fragments have a much better apparent affinity and hold their property of precipitation thanks to their bivalent form. The Fab fragments are monovalent. They are particularly recommended to hit hard-to-reach targets when molecule diffusion is a limiting factor.

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